BDBM50335817 6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)naphthalen-2-ol::CHEMBL1650646::US8546392, 54::US8546392, 70

SMILES COc1ccc(cn1)-c1c(O)ccc2cc(ccc12)-c1cccc(O)c1

InChI Key InChIKey=LGNVIXULXLACQS-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50335817   

Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  840nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  500nMAssay Description:The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  259nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  224nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  530nMAssay Description:Displacement of [3H]E2 from human placental 17beta-HSD2 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  33nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  670nMAssay Description:Displacement of [3H]E1 from 17beta-HSD1 in human T47D cells after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Universitaet Des Saarlandes

US Patent
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition assay using P450 CYP enzymes.More data for this Ligand-Target Pair
In DepthDetails US Patent