BDBM50335995 CHEMBL1669003::N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-6H-pyrrolo[3,4-g]quinolin-7(8H)-yl)benzyl)cyclopropylcarbamoyl)naphthalene-2-sulfonamide

SMILES Cc1cc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccc3ccccc3c2)ccc1N1Cc2c(C1=O)c(OCC(F)(F)F)c1cccnc1c2OCC(F)(F)F

InChI Key InChIKey=IISIFOJBGUAWEZ-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335995   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335995(N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-trifluoroeth...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335995(N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-trifluoroeth...)
Affinity DataIC50: 8.90nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335995(N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-trifluoroeth...)
Affinity DataKi:  21nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50335995(N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-trifluoroeth...)
Affinity DataIC50: 103nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed