BDBM50337140 11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one::CHEMBL1673052

SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C(C)C)c2n1)N1CCN(C)CC1

InChI Key InChIKey=YYTFTZONXCQXLW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50337140   

TargetSerine/threonine-protein kinase DCLK1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-CO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50: 98nMAssay Description:Inhibition of N-terminal 6His-tagged human ERK5 expressed in baculovirus infected Sf21 cells co-expressing HA-tagged human MEK5-DD using ARKKRRHPSGPP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50: 98nMAssay Description:Inhibition of ERK5 in human HeLa cells assessed as reduction in EGF-induced ERK5 autophosphorylation pretreated for 1 hr followed by EGF stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataEC50:  230nMAssay Description:Inhibition of EGF-stimulated ERK5 autophosphorylation in human HeLa cells preincubated with compound for 1 hrs followed by EGF stimulation for 17 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50: 230nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50: 289nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin) using LRRKtide as substrate incubated for 1 hrs in presence of ATP by Adapta TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed