BDBM50337503 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one::CHEMBL1682799

SMILES O=C1NCCc2cc(ccc12)C#Cc1ccccc1

InChI Key InChIKey=BOVJHNHRQNCDEQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50337503   

TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337503(6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one...)
Affinity DataEC50:  45nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337503(6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one...)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of mGlu5 receptor assessed as calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed