BDBM50337813 2-(4-(9H-fluoren-2-ylamino)-6-chloropyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid::CHEMBL1683869

SMILES OC(=O)C(Sc1nc(Cl)cc(Nc2ccc-3c(Cc4ccccc-34)c2)n1)c1cccc2ccccc12

InChI Key InChIKey=IJYPMVFBKQEZRI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50337813   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337813(2-(4-(9H-fluoren-2-ylamino)-6-chloropyrimidin-2-yl...)
Affinity DataIC50: 240nMAssay Description:Inhibition of 5-lipoxygenase in human PMNLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337813(2-(4-(9H-fluoren-2-ylamino)-6-chloropyrimidin-2-yl...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of mPGES-1 expressed in LPS-stimulated human A549 cells mitochondrial fraction assessed as conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50337813(2-(4-(9H-fluoren-2-ylamino)-6-chloropyrimidin-2-yl...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed