BDBM50338167 (R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide::CHEMBL1684954

SMILES C[C@@H](NC(=O)Cc1ccc(cc1)C1CC1)c1ccc(OCC(F)(F)F)cn1

InChI Key InChIKey=GEYDMBNDOVPFJL-CYBMUJFWSA-N

Data  1 KI  10 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50338167   

TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to Cav3.3 alpha1iMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of L-type Cav1.2 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at Cav3.3 alpha1i expressed in HEK293 cells at -100 mV by standard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  89nMAssay Description:Inhibition of Cav3.1 alpha1G at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3S]MK499 from human ERG in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent P/Q-type calcium channel subunit alpha-1A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of P/Q-type Cav2.1 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of N-type Cav2.2 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent R-type calcium channel subunit alpha-1E(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of R-type Cav2.3 at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  98nMAssay Description:Antagonist activity at Cav3.3 alpha1i expressed in HEK293 cells at -80 mV by standard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338167((R)-2-(4-cyclopropylphenyl)-N-(1-(5-(2,2,2-trifluo...)
Affinity DataIC50:  92nMAssay Description:Inhibition of Cav3.2 alpha1H at -80 mV holding potential by tandard voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair