BDBM50339575 4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-nitro-benzoic acid::CHEMBL1688763

SMILES OC(=O)c1ccc(Cn2cc(nn2)-c2ccc(cc2)-c2ccccc2)c(c1)[N+]([O-])=O

InChI Key InChIKey=RCZYVGFQNYJZNR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50339575   

TargetProstaglandin E synthase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339575(4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-ni...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Prostaglandin E2 synthase-1 in IL1-beta stimulated microsomal fraction of human A549 cell assessed as PGE2 level by RP-HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339575(4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-ni...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli MV1190 by cell free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339575(4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-ni...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339575(4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-ni...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339575(4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-ni...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed