BDBM50339828 CHEMBL1761087::N-((2S)-3-(6-cyanospiro[chroman-2,3'-piperidine]-1'-yl)-2-hydroxypropyl)-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide

SMILES CCOCCN(C[C@@H](O)CN1CCCC2(CCc3cc(ccc3O2)C#N)C1)S(=O)(=O)c1c(C)cccc1C

InChI Key InChIKey=JPBNLFIIFNMMLS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339828   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50339828(N-((2S)-3-(6-cyanospiro[chroman-2,3'-piperidine]-1...)
Affinity DataIC50: 170nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50339828(N-((2S)-3-(6-cyanospiro[chroman-2,3'-piperidine]-1...)
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of AKT1 in human LNCaP cells assessed as PRAS40 phosphorylation at Thr246 after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed