BDBM50340121 CHEMBL1760035::N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES COc1cc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc(OC)c1OC

InChI Key InChIKey=FHDPQTHZTKXVCW-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50340121   

TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 3nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 19nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 94nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 711nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 746nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 853nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50340121(N4-(quinolin-3-yl)-N2-(3,4,5-trimethoxyphenyl)pyri...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed