BDBM50340143 CHEMBL1760057::N2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-N4-(quinolin-3-yl)pyrimidine-2,4-diamine

SMILES C(COc1ccc(Nc2nccc(Nc3cnc4ccccc4c3)n2)cc1)CN1CCCCC1

InChI Key InChIKey=FXDWNCFVVOSWKM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50340143   

TargetInsulin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  24nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  81nMAssay Description:Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  4.13E+3nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  8.99E+3nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50340143(CHEMBL1760057 | N2-(4-(3-(piperidin-1-yl)propoxy)p...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed