BDBM50340459 CHEMBL1761873::Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl)-3-(4-fluorophenyl)-1-oxopropan-2-yl)-3,5-dimethylpiperazine-1-carboxamide

SMILES C[C@@H]1CN(C[C@@H](C)N1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C

InChI Key InChIKey=IVOZSKOYXPHCOQ-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50340459   

TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340459(Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-...)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340459(Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human MC4 receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340459(Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-...)
Affinity DataEC50:  260nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340459(Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-...)
Affinity DataIC50: 970nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340459(Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human MC5 receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340459(Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50340459(Trans-(3R,5R)-N-((R)-1-(4-(tert-butylcarbamoyl)-4-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed