BDBM50340539 (S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile::CHEMBL1762359

SMILES F[#6]-[#6]-[#8]-[#6]-[#6]-[#8]-c1ccc(-[#6]-[#7]-2-[#6](=O)\[#6](=[#6](/C#N)C#N)-c3cc(ccc-23)S(=O)(=O)[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6]-[#8]-c2ccccc2)cc1

InChI Key InChIKey=KCNBJVQVLWFWJJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50340539   

TargetCaspase-3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340539((S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-ox...)
Affinity DataIC50: 23.3nMAssay Description:Inhibition of human caspase 3 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-7(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340539((S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-ox...)
Affinity DataIC50: 70nMAssay Description:Inhibition of caspase 7 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-6(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340539((S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-ox...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-1(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340539((S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-ox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of caspase 1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCaspase-8(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50340539((S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-ox...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of caspase 8 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed