BDBM50340546 (S)-5-(2-((2,4-difluorophenoxy)methyl)azetidin-1-ylsulfonyl)-1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione::CHEMBL1762366

SMILES FCCn1cc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CC[C@H]2COc2ccc(F)cc2F)nn1

InChI Key InChIKey=IPBPQSZVGDLNHE-INIZCTEOSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340546   

TargetCaspase-1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340546((S)-5-(2-((2,4-difluorophenoxy)methyl)azetidin-1-y...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of caspase 1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340546((S)-5-(2-((2,4-difluorophenoxy)methyl)azetidin-1-y...)
Affinity DataIC50:  13.4nMAssay Description:Inhibition of human caspase 3 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340546((S)-5-(2-((2,4-difluorophenoxy)methyl)azetidin-1-y...)
Affinity DataEC50:  1.06E+3nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340546((S)-5-(2-((2,4-difluorophenoxy)methyl)azetidin-1-y...)
Affinity DataIC50:  15.3nMAssay Description:Inhibition of caspase 7 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340546((S)-5-(2-((2,4-difluorophenoxy)methyl)azetidin-1-y...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of caspase 8 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340546((S)-5-(2-((2,4-difluorophenoxy)methyl)azetidin-1-y...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed