BDBM50340574 CHEMBL1762527::N2-(3,5-dimorpholinophenyl)-N4-(5-methoxy-2-methylphenyl)-N4-methylpyrimidine-2,4-diamine

SMILES COc1ccc(C)c(c1)N(C)c1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1

InChI Key InChIKey=RIXPLQXGEZCOTA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50340574   

TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340574(N2-(3,5-dimorpholinophenyl)-N4-(5-methoxy-2-methyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340574(N2-(3,5-dimorpholinophenyl)-N4-(5-methoxy-2-methyl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340574(N2-(3,5-dimorpholinophenyl)-N4-(5-methoxy-2-methyl...)
Affinity DataIC50: 231nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340574(N2-(3,5-dimorpholinophenyl)-N4-(5-methoxy-2-methyl...)
Affinity DataIC50: 350nMAssay Description:Inhibition FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed