BDBM50340575 CHEMBL1762526::N4-(2,5-dimethylphenyl)-N2-(3,5-dimorpholinophenyl)-N4-methylpyrimidine-2,4-diamine

SMILES CN(c1ccnc(Nc2cc(cc(c2)N2CCOCC2)N2CCOCC2)n1)c1cc(C)ccc1C

InChI Key InChIKey=IAVMNGJNMUJPOX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50340575   

TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340575(N4-(2,5-dimethylphenyl)-N2-(3,5-dimorpholinophenyl...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340575(N4-(2,5-dimethylphenyl)-N2-(3,5-dimorpholinophenyl...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340575(N4-(2,5-dimethylphenyl)-N2-(3,5-dimorpholinophenyl...)
Affinity DataIC50: 965nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50340575(N4-(2,5-dimethylphenyl)-N2-(3,5-dimorpholinophenyl...)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed