BDBM50340675 (S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyran-2-yl)pyrimidin-2(1H)-one::CHEMBL1762220

SMILES Fc1cn([C@H]2OCC=CC2=O)c(=O)[nH]c1=O

InChI Key InChIKey=SEVHTONQYXGODI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340675   

TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340675((S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyr...)
Affinity DataIC50: 63nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340675((S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyr...)
Affinity DataIC50: 71nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340675((S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyr...)
Affinity DataIC50: 830nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340675((S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyr...)
Affinity DataIC50: 950nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340675((S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyr...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340675((S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed