BDBM50340679 CHEMBL1762230::exo-1-((2S,4S,5R)-4,5-dihydroxy-3-methylenetetrahydro-2H-pyran-2-yl)-5-fluoro-4-hydroxypyrimidin-2(1H)-one

SMILES O[C@@H]1CO[C@@H](C(=C)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O

InChI Key InChIKey=UXYOZHSRSIIWTB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50340679   

TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340679(exo-1-((2S,4S,5R)-4,5-dihydroxy-3-methylenetetrahy...)
Affinity DataIC50: 570nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340679(exo-1-((2S,4S,5R)-4,5-dihydroxy-3-methylenetetrahy...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340679(exo-1-((2S,4S,5R)-4,5-dihydroxy-3-methylenetetrahy...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340679(exo-1-((2S,4S,5R)-4,5-dihydroxy-3-methylenetetrahy...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetThymidylate synthase(Mouse)
University of Thessaly

Curated by ChEMBL
LigandPNGBDBM50340679(exo-1-((2S,4S,5R)-4,5-dihydroxy-3-methylenetetrahy...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed