BDBM50340933 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-phenylurea::CHEMBL1277253::N-{3-[6,7-Dimethoxyquinazolin-4-yloxy]phenyl}-N'-phenylurea::US9730937, Example 182

SMILES COc1cc2ncnc(Oc3cccc(NC(=O)Nc4ccccc4)c3)c2cc1OC

InChI Key InChIKey=XMINJNABOBQTEQ-UHFFFAOYSA-N

Data  5 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50340933   

TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataKd:  370nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Ambit Biosciences

US Patent
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataKd: >1.00E+3nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Ambit Biosciences

US Patent
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataKd: >1.00E+3nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataKd: >1.00E+3nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50340933(1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-ph...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of BRAF V600E mutant-dependent MEK phosphorylation in A375 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed