BDBM50341181 (3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-tert-butyl-benzylamino)-1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-ol::CHEMBL1760865

SMILES CC(C)(C)c1cccc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3ccc(O)c(Br)c3)[C@@H]2O)c1

InChI Key InChIKey=YHCNHDIDECZSCA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341181   

TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341181((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-tert-...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCathepsin D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341181((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-tert-...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341181((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-tert-...)
Affinity DataIC50: 550nMAssay Description:Inhibition of human BACE-1-mediated amyloid beta 40 release in APP-transfected human CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed