BDBM50341234 4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide::CHEMBL1765715

SMILES Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1

InChI Key InChIKey=WUGWDFMSJPJUEZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341234   

TargetPlatelet-derived growth factor receptor alpha(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341234(4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...)
Affinity DataIC50: 139nMAssay Description:Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into poly-Ala-Glu-Lys-Tyr after 60 mins by microplate scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341234(4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...)
Affinity DataIC50: 245nMAssay Description:Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50341234(4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...)
Affinity DataIC50: 6.95E+3nMAssay Description:Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into poly-Ala-Glu-Lys-Tyr after 60 mins by microplate scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed