BDBM50341300 CHEMBL1766038::N'-Acetyl-N'-ethyl-amino-thiazolo[5,4-b]-Ncyclopropylmethyl-morphinan

SMILES CCN(C(C)=O)c1nc2cc3c(C[C@@H]4[C@@H]5CCCC[C@]35CCN4CC3CC3)cc2s1

InChI Key InChIKey=IIQBOCVWMALJKQ-UWUFEASWSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341300   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341300(CHEMBL1766038 | N'-Acetyl-N'-ethyl-amino-thiazolo[...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341300(CHEMBL1766038 | N'-Acetyl-N'-ethyl-amino-thiazolo[...)
Affinity DataKi:  86nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341300(CHEMBL1766038 | N'-Acetyl-N'-ethyl-amino-thiazolo[...)
Affinity DataKi:  740nMAssay Description:Displacement of [3H]Naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed