BDBM50341444 (Z)-N-(3,5-Dichlorophenyl)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetamide::CHEMBL1766980

SMILES Clc1cc(Cl)cc(NC(=O)COc2ccc(\C=C3/SC(=O)NC3=O)cc2)c1

InChI Key InChIKey=BFCMVAIAYRXAMW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341444   

TargetProstaglandin G/H synthase 2(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341444((Z)-N-(3,5-Dichlorophenyl)-2-(4-((2,4-dioxothiazol...)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341444((Z)-N-(3,5-Dichlorophenyl)-2-(4-((2,4-dioxothiazol...)
Affinity DataIC50: 2.61E+4nMAssay Description:Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341444((Z)-N-(3,5-Dichlorophenyl)-2-(4-((2,4-dioxothiazol...)
Affinity DataIC50: 5.74E+4nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed