BDBM50341445 (Z)-N-(3,4-Difluorophenyl)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetamide::CHEMBL1766982

SMILES Fc1ccc(NC(=O)COc2ccc(\C=C3/SC(=O)NC3=O)cc2)cc1F

InChI Key InChIKey=HZIIRXYRFKZXAC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341445   

TargetProstaglandin G/H synthase 2(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341445((Z)-N-(3,4-Difluorophenyl)-2-(4-((2,4-dioxothiazol...)
Affinity DataIC50: 7.12E+3nMAssay Description:Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341445((Z)-N-(3,4-Difluorophenyl)-2-(4-((2,4-dioxothiazol...)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341445((Z)-N-(3,4-Difluorophenyl)-2-(4-((2,4-dioxothiazol...)
Affinity DataIC50: 3.41E+4nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed