BDBM50341446 (Z)-2-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)phenoxy)-N-(naphthalen-1-yl)acetamide::CHEMBL1766995

SMILES O=C(COc1ccc(\C=C2/SC(=O)NC2=O)cc1)Nc1cccc2ccccc12

InChI Key InChIKey=YVGYTVZZUKMAKU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341446   

TargetProstaglandin G/H synthase 2(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341446((Z)-2-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)p...)
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341446((Z)-2-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)p...)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50341446((Z)-2-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)p...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed