BDBM50342749 3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzamide::CHEMBL1771315

SMILES ONC(=O)c1cccc(c1)C(=O)N\N=C\c1ccccc1

InChI Key InChIKey=GMTCWDQOSDUWEX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50342749   

TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 52nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 52nMAssay Description:Inhibition of HDAC8 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of HDAC3 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed