BDBM50342750 CHEMBL1771484::N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)hydrazinyl)octanamide

SMILES ONC(=O)CCCCCCC(=O)NN=Cc1ccc(OCC#C)cc1

InChI Key InChIKey=YKIVECDGASVMLO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342750   

TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342750(N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342750(N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342750(N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)...)
Affinity DataIC50: 290nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed