BDBM50342753 3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-4-yl)methyl)benzylidene)hydrazinecarbonyl)-N-hydroxybenzamide::CHEMBL1771487

SMILES ONC(=O)c1cccc(c1)C(=O)NN=Cc1cccc(CN2C[C@@H](OC(=O)CC\C=C\CCC2=O)c2ccccc2)c1

InChI Key InChIKey=WIBGNIZQIHHGDX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342753   

TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342753(3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 110nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342753(3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342753(3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed