BDBM50343206 CHEMBL1773728::N-(6-(6-Chloro-5-(3-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide
SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1cnc(Cl)c(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c1
InChI Key InChIKey=LCGRAUSKPSGLOT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50343206
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataKi: <1nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair