BDBM50343417 1-[2-Chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1Hpyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1775046

SMILES ClC(Cn1ncc2c(NCc3ccncc3)ncnc12)c1ccc(Cl)cc1

InChI Key InChIKey=LHXWTIIFWARQLP-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50343417   

TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50343417(1-[2-Chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-...)
Affinity DataKi:  660nMAssay Description:Inhibition of human recombinant c-Abl by filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50343417(1-[2-Chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-...)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of human recombinant c-Src by filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50343417(1-[2-Chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-...)
Affinity DataIC50: 5.64E+4nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50343417(1-[2-Chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-...)
Affinity DataIC50: 5.64E+4nMAssay Description:Inhibition of Abl kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed