BDBM50343650 (2S,5S,8R,11S,14S,17S,20S)-5-((1H-indol-3-yl)methyl)-8,17-dibenzyl-2,11-bis(3-guanidinopropyl)-14-methyl-3,6,9,12,15,18,23-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosane-20-carboxamide::CHEMBL1775066

SMILES C[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O

InChI Key InChIKey=RSKJGGLMXZWIBS-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50343650   

TargetMelanocyte-stimulating hormone receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50343650((2S,5S,8R,11S,14S,17S,20S)-5-((1H-indol-3-yl)methy...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as increase in intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50343650((2S,5S,8R,11S,14S,17S,20S)-5-((1H-indol-3-yl)methy...)
Affinity DataIC50: 300nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50343650((2S,5S,8R,11S,14S,17S,20S)-5-((1H-indol-3-yl)methy...)
Affinity DataIC50: 400nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50343650((2S,5S,8R,11S,14S,17S,20S)-5-((1H-indol-3-yl)methy...)
Affinity DataIC50: 515nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50343650((2S,5S,8R,11S,14S,17S,20S)-5-((1H-indol-3-yl)methy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed