BDBM50343726 (S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile::CHEMBL1774056
SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(F)cc1C#N)c1ccc(F)cn1
InChI Key InChIKey=HIHOEGPXVVKJPP-JTQLQIEISA-N
Data 14 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50343726
Affinity DataIC50: <1nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Astrazeneca R&D Boston
Curated by ChEMBL
Astrazeneca R&D Boston
Curated by ChEMBL
Affinity DataIC50: 174nMAssay Description:Inhibition of human CDK2/cyclinEMore data for this Ligand-Target Pair
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EphB2More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Astrazeneca R&D Boston
Curated by ChEMBL
Astrazeneca R&D Boston
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
Affinity DataIC50: 129nMAssay Description:Inhibition of human Pyk2More data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Astrazeneca R&D Boston
Curated by ChEMBL
Astrazeneca R&D Boston
Curated by ChEMBL
Affinity DataIC50: 224nMAssay Description:Inhibition of human MuSkMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair