BDBM50343785 CHEMBL1774386::N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluorobutyl)-benzofuran-2-carboxamide

SMILES FC(CCNC(=O)c1cc2ccccc2o1)CN1CCN(CC1)c1cccc(Cl)c1Cl

InChI Key InChIKey=LRBUVURCWWAQQT-UHFFFAOYSA-N

Data  9 KI  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50343785   

TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKd:  0.0300nMAssay Description:Binding affinity to wild type human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKd:  0.0400nMAssay Description:Binding affinity to wild type human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [125I]-IABN from wild type human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  6.10nMAssay Description:Displacement of [125I]-IABN from human dopamine D3 receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in human HEK293 cell membrane for 1 hr by liquid scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataIC50: 430nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  960nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in human HEK293 cell membrane for 1 hr by liquid scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  1.15E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  5.34E+3nMAssay Description:Displacement of [125I]-IABN from human dopamine D4 receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi: >8.80E+3nMAssay Description:Displacement of [125I]DOI from 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  9.16E+3nMAssay Description:Displacement of [125I]-IABN from wild type human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50343785(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-fluo...)
Affinity DataKi:  1.46E+4nMAssay Description:Displacement of [125I]-IABN from human dopamine D2L receptor expressed in HEK293 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed