BDBM50343926 1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine::CHEMBL1775088

SMILES [O-][N+](=O)c1cccc(Oc2ccc(OCCN3CCCC3)cc2)c1

InChI Key InChIKey=QMBCKMBMGKATJW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50343926   

TargetLeukotriene A-4 hydrolase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human LTA4 hydrolase activity assessed as LTB4 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of purified COX1 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50343926(1-(2-(4-(3-Nitrophenoxy)phenoxy)ethyl)pyrrolidine ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of purified COX2 assessed as formation of oxidized TMPD during reduction og PGG2 to PGH2 preincubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed