BDBM50343959 CHEMBL1779630::rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxobutanamide

SMILES O[C@H]([C@@H](O)C(=O)N1CCCC1c1cccc(Cl)c1)C(=O)NCc1ccc(cc1)-n1cccn1

InChI Key InChIKey=BXLWVAKSQMYQKF-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50343959   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  4nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  120nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  602nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMatrilysin(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi:  4.70E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343959(rac-(2R,3R)-N-(4-(1H-pyrazol-1-yl)benzyl)-4-(2-(3-...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed