BDBM50344733 2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)benzamide::CHEMBL559968

SMILES Clc1ccccc1CCNC(=O)c1cc(ccc1Cl)-n1ncc(=O)[nH]c1=O

InChI Key InChIKey=KTRDEDJKFRJUOH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50344733   

TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344733(2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...)
Affinity DataIC50: 290nMAssay Description:Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344733(2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL1-beta release in presence of low ser...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344733(2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced YOPRO-1 uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344733(2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...)
Affinity DataIC50: 316nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344733(2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50344733(2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...)
Affinity DataIC50: 3.44E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed