BDBM50344734 2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)-N-((1-hydroxycycloheptyl)methyl)benzamide::CHEMBL560423

SMILES OC1(CNC(=O)c2cc(ccc2Cl)-n2ncc(=O)[nH]c2=O)CCCCCC1

InChI Key InChIKey=GUHUHCDILUWHDD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50344734   

TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344734(2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced YOPRO-1 uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344734(2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344734(2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344734(2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...)
Affinity DataIC50: 447nMAssay Description:Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed