BDBM50344747 2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)-N-((1-hydroxycyclohexyl)methyl)benzamide::CHEMBL559079

SMILES OC1(CNC(=O)c2cc(ccc2Cl)-n2ncc(=O)[nH]c2=O)CCCCC1

InChI Key InChIKey=MIFNWOQKBBQBPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344747   

TargetP2X purinoceptor 7(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50344747(2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...)
Affinity DataIC50: 398nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50344747(2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed