BDBM50345388 5-Methyl-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-[1,2,4]triazolo-[1,5-a]pyrimidin-7-amine::CHEMBL1784593::US9238653, Table 5, Compound 1

SMILES Cc1cc(NC2CCc3ccccc3C2)n2ncnc2n1

InChI Key InChIKey=BOTVJBHLFOCPPM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345388   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Texas

US Patent
LigandPNGBDBM50345388(5-Methyl-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-[1,...)
Affinity DataIC50: 500nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50345388(5-Methyl-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-[1,...)
Affinity DataIC50: 540nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed