BDBM50345510 CHEMBL1784365::N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperidin-1-ylsulfonyl)methyl)tetrahydro-2H-pyran-4-yl)-N-hydroxyformamide::US10322143, Compound 13i

SMILES Cc1cc(C)c(CCC2CCN(CC2)S(=O)(=O)CC2(CCOCC2)N(O)C=O)cn1

InChI Key InChIKey=OFQBKLDPHHFEPJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50345510   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Universitetet I Oslo

US Patent
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 130nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Universitetet I Oslo

US Patent
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 130nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345510(N-(4-((4-(2-(4,6-dimethylpyridin-3-yl)ethyl)piperi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed