BDBM50345522 CHEMBL1784347::N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-piperidine-1-sulfonylmethyl}-1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl)-N-hydroxy-formamide::US10322143, Compound 14g

SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCS(=O)(=O)CC1)N(O)C=O

InChI Key InChIKey=IWRJDNKXMJBFEA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50345522   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Universitetet I Oslo

US Patent
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 16nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Human)
Universitetet I Oslo

US Patent
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 16nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 270nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345522(N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed