BDBM50345529 CHEMBL1784354::N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-methylpropan-2-yl)-N-hydroxyformamide

SMILES CC(C)(CS(=O)(=O)N1CCN(CC1)c1ccc(F)cc1)N(O)C=O

InChI Key InChIKey=JKTGELXOMXEKJI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50345529   

LigandPNGBDBM50345529(N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345529(N-(1-(4-(4-fluorophenyl)piperazin-1-ylsulfonyl)-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed