BDBM50345900 CHEMBL1783837::N-cyclopropyl-4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzenesulfonamide

SMILES CN(C)[C@@H]1CCC[C@H]1Nc1nc(Nc2ccc(cc2)S(=O)(=O)NC2CC2)ncc1C(F)(F)F

InChI Key InChIKey=HSRFESCGWSJMOZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50345900   

TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345900(N-cyclopropyl-4-(4-((1R,2R)-2-(dimethylamino)cyclo...)
Affinity DataIC50: 95nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345900(N-cyclopropyl-4-(4-((1R,2R)-2-(dimethylamino)cyclo...)
Affinity DataIC50: 140nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphorylation by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345900(N-cyclopropyl-4-(4-((1R,2R)-2-(dimethylamino)cyclo...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed