BDBM50347983 CHEMBL1800158

SMILES CONC(=O)Nc1ccc(cc1)-c1sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccc(OC)nc3)c(=O)c2c1CN(C)C

InChI Key InChIKey=DUZGTINKFAHXDT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50347983   

TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347983(CHEMBL1800158)
Affinity DataIC50: 0.120nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347983(CHEMBL1800158)
Affinity DataIC50: 0.260nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347983(CHEMBL1800158)
Affinity DataIC50: 0.550nMAssay Description:Displacement of [125I]leuprorelin from recombinant human GnRH receptor expressed in CHO cells after 60 mins by X-ray counter in presence of 40% fetal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50347983(CHEMBL1800158)
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at human GnRH receptor expressed in CHO cells assessed as inhibition of GnRH-induced arachidonic acid release using [5,6,8,9,11,1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed