BDBM50348732 CHEMBL1801504

SMILES O=c1cc(Cn2c(C3CCC3)nc3nccnc32)c2ccc(F)c(F)c2[nH]1

InChI Key InChIKey=ISGGXCWQSOCOCW-UHFFFAOYSA-N

Data  2 IC50  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50348732   

TargetNitric oxide synthase, inducible(Human)
Afraxis

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataIC50: 91nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Afraxis

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50:  91nMAssay Description:Inhibition of human iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50:  300nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as inhibition ionomycin induced nitric oxide production incubated for 24 hrs measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50:  430nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataIC50: 500nMAssay Description:Inhibition of mouse iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50:  1.65E+4nMAssay Description:Inhibition of human eNOS expressed in HEK293 cells assessed as inhibition A23187 induced nitric oxide production incubated for 24 hrs measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50: >3.80E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50: >6.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Kalypsys

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348732BDBM50348732(CHEMBL1801504)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed