BDBM50348759 CHEMBL1806874

SMILES CCCN1CCc2cccc-3c2[C@H]1Cc1cccc(OC(=O)CCCCC2CCSS2)c-31

InChI Key InChIKey=JCKSBFDVTFRZJP-UHFFFAOYSA-N

Data  3 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50348759   

Target5-hydroxytryptamine receptor 1A(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor expressed in CHO cells after 50 mins by beta liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataKi:  137nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor expressed in CHO cells after 50 mins by beta liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataKi:  174nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataEC50:  190nMAssay Description:Agonist activity at 5-HT1A receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataEC50:  320nMAssay Description:Agonist activity at dopamine D2 receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at adrenergic Alpha-1D receptor expressed in HEK293 cells co-transfected with Galpha16 assessed as inhibition of adrenaline-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at adrenergic Alpha-1B receptor expressed in CHO cells assessed as inhibition of adrenaline-induced intracellular calcium after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at adrenergic beta2 receptor expressed in HEK293 cells co-transfected with Galpha16 assessed as inhibition of adrenaline-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Soochow University College of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50348759(CHEMBL1806874)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at adrenergic alpha1A receptor expressed in CHO cells assessed as inhibition of adrenaline-induced intracellular calcium level af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed