BDBM50349282 CHEMBL1808284::CHEMBL1813096
SMILES Oc1c2CN(CCn2c(=O)n1[C@H]1C[C@@H]1c1ccccc1)C(=O)Nc1ccccc1-c1ccccc1
InChI Key InChIKey=VRAGZVBBLPIIJU-VWNXMTODSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50349282
Affinity DataIC50: 48nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 20% normal human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Displacement of [125I]-PA cyclopamine from smoothened expressed in african green monkey COS-1 cells after 10 mins by autoradiographyMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibition of Hh pathwayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair