BDBM50350281 CHEMBL1812527

SMILES Clc1cccc2c(\C=C\c3cccnc3)c[nH]c12

InChI Key InChIKey=IVKXDSVPJPLQDR-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50350281   

TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350281(CHEMBL1812527)
Affinity DataKi:  2.10E+4nMAssay Description:Competitive inhibition of human purified TDO by Henri-Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350281(CHEMBL1812527)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human purified TDO assessed as initial rate of L-Trp oxidation at 100 uM of substrate concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350281(CHEMBL1812527)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human purified TDO assessed as formation of kynurenine from N-formylkynurenine preincubated for 10 mins measured after 5 to 20 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
University of Namur

Curated by ChEMBL
LigandPNGBDBM50350281(CHEMBL1812527)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed