BDBM50350750 CHEMBL1818300

SMILES CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(nc3ccccc23)N2CCC(CCN3CC(O)C3)CC2)CC1

InChI Key InChIKey=DLXYCZXEBQOCAR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50350750   

TargetAcetyl-CoA carboxylase 2(Human)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50350750(CHEMBL1818300)
Affinity DataIC50: 99nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase(Rat)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50350750(CHEMBL1818300)
Affinity DataIC50: 150nMAssay Description:Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Rat)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50350750(CHEMBL1818300)
Affinity DataIC50: 250nMAssay Description:Inhibition of obese Zucker rat ACC1 assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50350750(CHEMBL1818300)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant his-tagged ACC1 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Research and Development

Curated by ChEMBL
LigandPNGBDBM50350750(CHEMBL1818300)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed