BDBM50353440 CHEMBL1829864::US10196373, Compound 45F

SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1cccc2cccnc12

InChI Key InChIKey=WHDNFPSXKYIUAR-UHFFFAOYSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50353440   

TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353440(CHEMBL1829864 | US10196373, Compound 45F)
Affinity DataKi:  5.66E+3nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353440(CHEMBL1829864 | US10196373, Compound 45F)
Affinity DataKi:  4.10E+4nMAssay Description:Inhibition of STAT3 using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 15 mins by fluorescence polarisation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353440(CHEMBL1829864 | US10196373, Compound 45F)
Affinity DataKi:  4.10E+4nMAssay Description:ChIP assay was performed using EZ ChIP Kit (Millipore, Billerica, Mass., USA) as per manufacturer's instruction. Briefly, after crosslinking with...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353440(CHEMBL1829864 | US10196373, Compound 45F)
Affinity DataIC50:  2.46E+4nMAssay Description:ChIP assay was performed using EZ ChIP Kit (Millipore, Billerica, Mass., USA) as per manufacturer's instruction. Briefly, after crosslinking with...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353440(CHEMBL1829864 | US10196373, Compound 45F)
Affinity DataIC50:  2.46E+4nMAssay Description:Inhibition of STAT3 in mouse NIH3T3/vSrc nuclear extract assessed as disruption of the Stat3-DNA complex pre-incubated for 30 mins by EMSA analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353440(CHEMBL1829864 | US10196373, Compound 45F)
Affinity DataIC50:  6.20E+3nMAssay Description:In vitro inhibitory activity towards Coagulation factor X was determined using chromogenic substrate, MeO-COD-CHG-Gly-Arg-pNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase S(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50353440(CHEMBL1829864 | US10196373, Compound 45F)
Affinity DataIC50:  4.30E+3nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed