BDBM50355706 CHEMBL1910989

SMILES Cc1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1

InChI Key InChIKey=JEDLLKZKXSMSBV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50355706   

LigandPNGBDBM50355706(CHEMBL1910989)
Affinity DataIC50: 143nMAssay Description:Inhibition of mouse recombinant PI3K p110alpha expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Monash Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50355706(CHEMBL1910989)
Affinity DataIC50: 187nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50355706(CHEMBL1910989)
Affinity DataIC50: 289nMAssay Description:Inhibition of human recombinant PI3K p110beta expressed in Sf21 insect cells using phosphatidylinositol as substrate after 1 hr by phosphoimagingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Monash Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50355706(CHEMBL1910989)
Affinity DataIC50: 290nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50355706(CHEMBL1910989)
Affinity DataIC50: 523nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Monash Institute of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50355706(CHEMBL1910989)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) expressed in SF21 cells using phosphatidylinositol as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed